Welcome to our website!

Clinical study of Pu Yuan and stomach capsule combined with domperidone treatment of functional dyspepsia


Abstract Objective To evalsuate the Pu Yuan and stomach capsule combined with domperidone treatment of functional dyspepsia (FD) patients. Methods: June 2009 - FD patients in October 2010 in our hospital 130 cases were randomly divided into two groups, the control group, domperidone (domperidone) treatment, the treatment group with Po on the basis of the control group yuan and stomach capsules. Four weeks after the observation of clinical effect and improvement of symptoms Results: After treatment, patients symptoms before treatment significantly decreased integration than those in the treatment group postprandial abdominal fullness, upper abdominal pain, belching, the degree of improvement of appetite is particularly significant compared with the control group the difference was significant (P <0.05). Conclusion: Pu Yuan and stomach capsule combined with domperidone can significantly improve the clinical symptoms of functional dyspepsia with better clinical efficacy.

Key words functional dyspepsia, Pu Yuan and stomach capsule, domperidone.

Functional dyspepsia (FD) is clinically the most common functional gastrointestinal disorders, their prevalsence, and showed an increasing trend. 20% to 30% of the Western countries FD accounts for digestive diseases, while in China, accounting for about 30% to digest more than 40 percent of medical outpatients number [1-2]. Patients presented with abdominal pain, early satiety, epigastric burning sensation and other symptoms, often accompanied by clinical manifestations of insomnia, anxiety, panic, chest tightness, and so on. Difficult to treat and difficult to control symptoms persist. 130 cases of FD patients in hospital in June 2009 and 2010 were given 10 yuan Po + and stomach and domperidone domperidone therapy alone and combination therapy with a single drug for clinical comparison, the results reported below :

1. clinical information

1.1 General Conditions Select our hospital outpatient FD 130 patients. Inclusion criteria: diagnosis Rome Ⅲ criteria. Patients with recurrent dyspeptic symptoms: postprandial discomfort, upper abdominal pain; endoscopy found no gastric and duodenal ulcers, esophagitis, erosive and other organic disease and H. pylori were negative; one week before the visit did not take any acid, acid suppression and prokinetic drugs, informed consent of patients, with follow-up. Exclusion criteria: determined to lung and kidney dysfunction; suspected malignant lesions; gastroscopy can diagnose gastroesophageal reflux, erosive gastritis; pregnant and lactating women; drug allergy and unwilling collaborators. The 130 patients were randomly divided into treatment group of 65 patients in the control group of 65 cases. Two groups of patients gender, average age, duration of symptoms and disease and other constituent ratio difference was not statistically significant (P <0.05).

1.2 treatment group: Pu Yuan and stomach capsule (imperial Qingdao Huaren Pharmaceutical Co., Ltd.) taking half an hour after a meal, once four, three times a day; domperidone (Janssen) 10mg tid half an hour before taking. Control group: Motilium (Janssen) 10mg tid half an hour before taking a course of four weeks, avoid alcohol during treatment, the treatment of gastritis and disable the other drugs.

1.3 determine the efficacy

1.3.1 markedly: symptoms improved ≥70%; effective: symptoms improved ≥50%; improved: symptoms> 30%; invalid: symptoms improved ≤30%; the total efficiency = [(+ markedly effective) / total cases] × 100%.

1.3.2 GSRS symptom score using the scoring method [3]: 0 is divided into asymptomatic; after 1 divided reminder can realize symptoms are present; symptoms were divided into 2, but does not affect the working life. Observed on abdominal pain, bloating, belching, five common symptoms of early satiety, nausea and vomiting.

1.4 statistical methods using SPSS 12.0 statistical software for statistical treatment, and symptom scores before and after treatment efficacy between the two groups using analysis of variance and t test P≤0.05 was considered statistically different.

2. result:

The clinical efficacy of dyspeptic symptoms compared to total efficiency of treatment group was significantly higher, the difference was statistically significant (P≤0.05); treatment group symptom score decreased significantly compared with the control group, the difference was significant Table.

 

Group Cases symptom score improved markedly effective invalid total efficiency (%)

           (± s)

The treatment group 65 4.57 ± 2.03 47 10 4 4 87.7%

The control group 65 11.21 ± 2.35 20 16 15 14 55.4%

3 Discussion

FD refers to pain or discomfort in the upper abdomen symptoms of chronic persistent or recurrent, including abdominal pain, bloating, early satiety and postprandial satiety, etc., and routine inspection found no organic cause of a group of clinical syndrome. Etiology and pathogenesis is not entirely clear, but now that it may include the following factors: (1) inflammation of the stomach or duodenum; (2) gastric motility dysfunction; (3) gastric sensory function abnormalities; ( 4) H. pylori infection; (5) abnormal gastric electrical activity; (6) low vagus nerve tension; (7) diet, emotional, and psychological factors. Currently, the clinical treatment of FD mainly acid suppression, regulate motility, depression anxiety, aid digestion. Domperidone is a dopamine receptor antagonist, dopamine receptor by antagonizing the gastrointestinal tract, specifically acting on the digestive tract, can enhance gastric motility, and promote gastric emptying, increased gastric antral contractions, coordination stomach and duodenal bowel movements, effectively relieve symptoms of upper gastrointestinal motility disorders, it is one commonly used in clinical prokinetic agents. Pu Yuan and stomach capsule (imperial Qingdao Huaren Pharmaceutical Co., Ltd.) is the main component Corydalis, Cyperus, frankincense (system), dandelion, alum (calcined), licorice, accessories for starch, times he cyclodextrin. In its liver and stomach, qi pain, for the law to saprophytic new, natural selection of traditional Chinese medicine, according to the testimonies monarch strict prescriptions, while inhibiting and killing Helicobacter pylori, inhibition of gastric acid secretion; on the other hand protect the gastric mucosa, improve immunity, enhance gastric motility, ulcers promote repair and regeneration, reduce the incidence of drug resistance, effectively prevent recurrence. Pu Yuan and stomach capsule treat epigastric pain, belching acid reflux, irritability, threatening inflation and other functional dyspepsia, rapid onset of effect is significant, stable and effective relapse prevention, non-toxic side effects, clinical medication safety. FD onset gastrointestinal dynamic force, psychiatric, psychological factors are closely related. Prokinetic, anxiolytic, antidepressant medication and psychological therapy, Chinese medicine treatment have a certain effect, in which the effect of combined treatment is better [4]. This study showed that the combination therapy group was significantly better than western medicine group, and the clinical symptoms of FD patients had significant improvement. Description of Integrative Medicine is an effective treatment of FD, worthy of clinical application.

references:

[1] Cai Xin. Mosapride, multi-level game combined treatment of functional dyspepsia observed 61 cases [J] Chongqing Medicine, 2007,36 (22);. 2334

. [2] Wang Yun-Fat trimebutine joint compound digestive enzyme therapy in patients with functional dyspepsia efficacy [J] Chinese General Practice, 2009,12 (15); 415

[3] JAN.S, INGEMAR S, GERHARD D.GSRS-a clincal rating scale for gastro-intestinal symptoms in patients with irritable bowel syndroom and peptic ulcer disease [J] .Didestive Diseases and sciences, 1998,33 (2): 129-134

. [4] Lianzhi treatment of advanced functional dyspepsia [J] Jiangxi medicine .2008,39 (4): 69-70.

Contact: Diao Xing Yuan 13,963,487,135


Imperial Qingdao Huaren Pharmaceutical Co., Ltd.
Address: East Road, Qingdao High-tech Industrial Development Zone, No. 373

Website:www.178tlc.com         Tel:86-0532-87970001 4008-111-277    Fax:86-0532-87970003      

未标题-4.png